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JCEM

世界トップレベルの内分泌臨床研究と最先端のClinical Practice Reviewに関する査読誌です。

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Vol.102 Issue 9

グルカゴンはIGF結合蛋白質を調節することによりインスリンとは無関係にIGF-1の生理活性を低下させる

Glucagon decreases IGF-1 bioactivity in humans, independently of insulin, by modulating its binding proteins

Zeinab Sarem, Christiane Bumke-Vogt, Ayman M Mahmoud, Biruhalem Assefa, Martin O Weickert, Aikatarini Adamidou, Volker Bahr, Jan Frystyk, Matthias Mohlig, Joachim Spranger Stefanie Lieske, Andreas L Birkenfeld, Andreas F H Pfeiffer, Ayman M Arafat

Vol.102 Issue 9

悪性褐色細胞腫と傍神経節細胞腫:55歳超の272症例

Malignant Pheochromocytoma and Paraganglioma: 272 Patients over 55 Years

Oksana Hamidi, William F Young, Jr., Nicole M Iniguez-Ariza, Nana Esi Kittah, Lucinda Gruber, Cristian Bancos, Shrikant Tamhane, Irina Bancos

Vol.102 Issue 9

キスぺプチンはヒト胎児において副腎皮質の発達およびその機能に対する新たな調節因子である:ヒト胎児胎盤系にとって重要な意義のある知見

Kisspeptin is a novel regulator of human fetal adrenocortical development and function - A finding with important implications for the human feto - placental unit

Harshini Katugampola, Peter J King, Sumana Chatterjee, Muriel Meso, Andrew J Duncan, John C Achermann, Leo Guasti, Lea Ghataore, Norman F Taylor, Rebecca Allen Shemoon Marlene, Joseph Aquilina, Ali Abbara, Channa N Jaysena, Waljit S Dhillo, Leo Dunkel, Ulla Sankilampi, Helen L Storr

Vol.102 Issue 9

成人2型糖尿病患者における心血管疾患と平均余命;韓国における全国規模の抽出コホート研究

Cardiovascular Diseases and Life Expectancy in Adults with Type 2 Diabetes; A Korean National Sample Cohort Study

Yu Mi Kang, Yun Kyung Cho, Seung Eun Lee, Joong-Yeol Park, Woo Je Lee, Ye-Jee Kim, Chang Hee Jung

Vol.102 Issue 9

胎児期における母体の高濃度甲状腺ホルモンへの曝露はヒトおよびマウスにおいて成長後の中枢性甲状腺ホルモン不応症を惹起する

Fetal exposure to high maternal thyroid hormone (TH) levels causes central resistance to TH in adult humans and mice

Panudda Srichomkwun, Joao Anselmo, Xiao-Hui Liao, G Sebastian Hones, Lars C Moeller, Manuela Alonso-Sampedro, Roy E Weiss, Alexandra M Dumitrescu, Samuel Refetoff

Vol.102 Issue 9

PCSK9の機能喪失型変異が食後の脂質およびアポリポ蛋白質Bの反応性に及ぼす影響

The Effect of PCSK9 Loss-of-Function Variants on the Postprandial Lipid and ApoB-Lipoprotein Response

Teik Chye Ooi, Jacqueline A Krysa, Seham Chaker, Hussein Abujrad, Janice Mayne, Kathy Henry, Marion Cousins, Angela Raymond, Colette Favreau, Monica Taljaard Michel Chretien, Majambu Mbikay, Spencer D Proctor, Donna F Vine

Vol.102 Issue 9

甲状腺機能、心血管疾患の危険因子と粥状硬化性心血管性疾患の発症:地域における粥状硬化症リスク(ARIC)試験

Thyroid Function, Cardiovascular Risk Factors, and Incident Atherosclerotic Cardiovascular Disease: The Atherosclerosis Risk in Communities (ARIC) Study

Seth S Martin, Natalie Daya, Pamela L Lutsey, Kunihiro Matsushita, Anna Fretz, John W McEvoy, Roger S Blumenthal, Josef Coresh, Philip Greenland, Anna Kottgen Elizabeth Selvin

Vol.102 Issue 8

若年発症成人型糖尿病における遺伝子変異の多様性は糖尿病に対する予防的療法への反応性に影響する

Variation in Maturity-Onset Diabetes of the Young genes influence response to interventions for diabetes prevention

Liana K. Billings, Kathleen A. Jablonski, A. Sofia Warner1, Yu-Chien Cheng, Jarred B. McAteer, Laura Tipton, Alan R. Shuldiner, David A. Ehrmann, Alisa K. Manning, Dana Dabelea, Paul W. Franks, Steven E. Kahn, Toni I. Pollin, William C. Knowler, David Altshuler, Jose C. Florez for the Diabetes Prevention Program Research Group

Vol.102 Issue 8

非HLA領域の一塩基多型は1型糖尿病のリスクを有するトライアルネット患者親族のリスク層別化に役立つか

Can non-HLA Single Nucleotide Polymorphisms Help Stratify Risk in TrialNet Relatives at Risk for Type 1 Diabetes

Andrea K. Steck, Ping Xu, Susan Geyer, Maria J. Redondo, Peter Antinozzi, John M. Wentworth, Jay Sosenko, Suna Onengut-Gumuscu, Wei-Min Chen, Stephen S. Rich, Alberto Pugliese, and the Type 1 Diabetes TrialNet Study Group

Vol.102 Issue 8

1型糖尿病患者の膵臓にはベータ細胞が残存するが細胞分裂の継続も他細胞からの新生も認められなかった

β-cells persist in T1D pancreata without evidence for ongoing β-cell turnover or neogenesis

Carol J. Lam, Daniel R. Jacobson, Matthew M. Rankin, Aaron R. Cox, Jake A. Kushner

Vol.102 Issue 8

USP8遺伝子の体細胞変異は小児クッシング病の頻度の高い原因である

Somatic USP8 gene mutations are a common cause of pediatric Cushing disease

Fabio R. Faucz, Amit Tirosh, Christina Tatsi, Annabel Berthon, Laura C. Hernández-Ramírez, Nikolaos Settas, Anna Angelousi, Ricardo Correa, Georgios Z. Papadakis, Prashant Chittiboina, Martha Quezado, Nathan Pankratz, John Lane, Aggeliki Dimopoulos, James L. Mills, Maya Lodish, Constantine A. Stratakis

Vol.102 Issue 8

高血糖およびヘリコバクターピロリ感染が大腸腺腫発症リスクに及ぼす相乗効果

Synergistic effect of hyperglycemia and Helicobacter pylori infection status on colorectal adenoma risk

Kuang-Chun Hu, Ming-Shiang Wu, Cheng-Hsin Chu, Horng-Yuan Wang, Shee-Chan Lin, Sung-Chen Liu, Chuan-Chuan Liu, Tung-Hung Su, Chi-Ling Chen, Chun-Jen Liu, Shou-Chuan Shih

Vol.102 Issue 8

若年性肥満:従来認められていなかったGNAS遺伝子変異およびメチル化異常の最初の徴候

EARLY-ONSET OBESITY: UNRECOGNIZED FIRST EVIDENCE FOR GNAS MUTATIONS AND METHYLATION CHANGES

Annette Grüters-Kieslich, Monica Reyes, Amita Sharma, Cem Demirci, Terry J. DeClue, Erwin Lankes, Dov Tiosano, Dirk Schnabel, Harald Jüppner

Vol.102 Issue 8

高血糖の代替指標と地域社会におけるアルツハイマー病発症リスク:久山町研究

Alternative measures of hyperglycemia and risk of Alzheimer's disease in the community: the Hisayama Study

Naoko Mukai, Tomoyuki Ohara, Jun Hata, Yoichiro Hirakawa, Daigo Yoshida, Hiro Kishimoto, Masafumi Koga, Udai Nakamura, Takanari Kitazono, Yutaka Kiyohara, and Toshiharu Ninomiya

Vol.102 Issue 8

グリコゲニン1欠損患者でのグリコーゲン合成:筋肉におけるグリコゲニン2の役割

Glycogen synthesis in glycogenin 1 deficient patients; a role for glycogenin 2 in muscle

Thomas O. Krag, Cristina Ruiz Ruiz, John Vissing

Vol.102 Issue 8

コピー数多型は若年性肥満患者に多くみられ、新たな発病経路の存在が明らかになった

Copy number variants are enriched in individuals with early-onset obesity and highlight novel pathogenic pathways

Maria Pettersson, Heli Viljakainen, Petra Loid, Taina Mustila, Minna Pekkinen, Miriam Armenio, Johanna C Andersson-Assarsson, Outi Mäkitie, Anna Lindstrand

Vol.102 Issue 8

1型糖尿病成人の非重症低血糖症に対する低用量グルカゴン治療の有効性と安全性

Efficacy and Safety of Mini-dose Glucagon for Treatment of Non-severe Hypoglycemia in Adults with Type 1 Diabetes

Morey W. Haymond, Stephanie N. DuBose, Michael R. Rickels, Howard Wolpert, Viral N Shah,  Jennifer L. Sherr, Ruth S. Weinstock, Shivani Agarwal, Alandra S. Verdejo, Martin J. Cummins, Brett Newswanger, Roy W. Beck, for the T1D Exchange Mini-dose Glucagon Study Group

Vol.102 Issue 8

出生前のコレカルシフェロール補充に対する反応性はビタミンD関連遺伝子の頻度の高い変異と関連する

Response to antenatal cholecalciferol supplementation is associated with common vitamin D related genetic variants

Rebecca J Moon, Nicholas C Harvey, Cyrus Cooper, Stefania D’Angelo, Elizabeth M Curtis, Sarah R Crozier, Sheila J. Barton, Sian M Robinson, Keith M Godfrey, Nikki J Graham, John W Holloway, Nicholas J Bishop, Stephen Kennedy, Aris T Papageorghiou, Inez Schoenmakers, Robert Fraser, Saurabh V Gandhi, Ann Prentice, Hazel M Inskip, M Kassim Javaid and the MAVIDOS Trial Group

Vol.102 Issue 7

適正な黄体機能の維持:マイクロRNA96は黄体細胞の生存およびプロゲステロン産生を促進する

The adequate corpus luteum: miR-96 promotes luteal cell survival and progesterone production

Bushra T. Mohammed, Sadanand D. Sontakke, Jason Ioannidis, W. Colin Duncan, F. Xavier Donadeu

Vol.102 Issue 7

周閉経期女性の月経周期の変化:全米規模の女性の健康調査(SWAN)

Menstrual Cycle Hormone Changes in Women Traversing the Menopause: Study of Women's Health Across the Nation

Nanette Santoro, Sybil L. Crawford, Samar R. El Khoudary, Amanda A. Allshouse, Sherri-Ann Burnett-Bowie, Joel Finkelstein, Carol Derby, Karen Matthews, Howard M. Kravitz, Sioban D. Harlow, Gail A. Greendale, Ellen B. Gold, Rasa Kazlauskaite, Dan McConnell, Genevieve Neal-Perry, Jelena Pavlovic John Randolph, Gerson Weiss, Hsiang-Yu Chen, Bill Lasley