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世界トップレベルの内分泌臨床研究と最先端のClinical Practice Reviewに関する査読誌です。

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Vol.102 Issue 6

血管疾患、自律性のアルドステロン症および鉱質コルチコイド受容体活性化に特徴的なレニンの反応性

Renin Phenotypes Characterize Vascular Disease, Autonomous Aldosteronism, and Mineralocorticoid Receptor Activity

Gregory L. Hundemer, Rene Baudrand, Jenifer M. Brown, Gary Curhan, Gordon H. Williams, Anand Vaidya

Vol.102 Issue 6

特発性低性腺刺激ホルモン型性腺機能低下症におけるCCDC141の突然変異

CCDC141 Mutations in Idiopathic Hypogonadotropic Hypogonadism

Ihsan Turan, B. Ian Hutchins, Bulent Hacihamdioglu, L. Damla Kotan, Fatih Gurbuz, Ayca Ulubay, Eda Mengen, Bilgin Yuksel, Susan Wray, A. Kemal Topaloglu

Vol.102 Issue 6

一次治療後に再増殖する非機能性下垂体腺腫の転帰:イギリスの2つの大規模施設における研究

Outcome of Nonfunctioning Pituitary Adenomas That Regrow After Primary Treatment: A Study From Two Large UK Centers

Metaxia Tampourlou, Georgia Ntali, Shahzada Ahmed, Wiebke Arlt, John Ayuk, James V. Byrne, Swarupsinh Chavda, Simon Cudlip, Neil Gittoes, Ashley Grossman,   Rosalind Mitchell, Michael W. O’Reilly, Alessandro Paluzzi, Andrew Toogood, John A. H. Wass, Niki Karavitaki

Vol.102 Issue 6

多様な治療を実施した甲状腺未分化癌患者におけるPD-1およびPD-L1の発現:後向き研究の成績

Expression of PD-1 and PD-L1 in Anaplastic Thyroid Cancer Patients Treated With Multimodal Therapy: Results From a Retrospective Study

Ashish V. Chintakuntlawar, Kandelaria M. Rumilla, Carin Y. Smith, Sarah M. Jenkins, Robert L. Foote, Jan L. Kasperbauer, John C. Morris, Mabel Ryder, Samer Alsidawi, Crystal Hilger,   Keith C. Bible

Vol.102 Issue 6

多嚢胞性卵巣症候群女性における必要エネルギー量の評価:二重標識水法との比較

Assessing Energy Requirements in Women With Polycystic Ovary Syndrome: A Comparison Against Doubly Labeled Water

Nicholas T. Broskey, Monica C. Klempel, L. Anne Gilmore, Elizabeth F. Sutton, Abby D. Altazan, Jeffrey H. Burton, Eric Ravussin, Leanne M. Redman

Vol.102 Issue 6

混合カロチノイドが小児におけるアディポカインおよび腹部脂肪蓄積に及ぼす効果:予備的研究の結果

Effects of Mixed Carotenoids on Adipokines and Abdominal Adiposity in Children: A Pilot Study

J. Atilio Canas, Amanda Lochrie, Amy Galena McGowan, Jobayer Hossain, Christopher Schettino, P. Babu Balagopal

Vol.102 Issue 6

肥満は炎症、脂質代謝および卵母細胞の遺伝子発現を調節する:単一細胞トランスクリプトームの観点から

Obesity Modulates Inflammation and Lipid Metabolism Oocyte Gene Expression: A Single-Cell Transcriptome Perspective

Meghan L. Ruebel, Matthew Cotter, Clark R. Sims, Dean M. Moutos, Thomas M. Badger, Mario A. Cleves, Kartik Shankar, Aline Andres

Vol.102 Issue 6

長時間座位を中断することは2型糖尿病成人患者において食後の血漿脂質プロファイルを変化させる

Breaking Up Prolonged Sitting Alters the Postprandial Plasma Lipidomic Profile of Adults With Type 2 Diabetes

Megan S. Grace, Paddy C. Dempsey, Parneet Sethi, Piyushkumar A. Mundra, Natalie A. Mellett, Jacquelyn M. Weir, Neville Owen, David W. Dunstan, Peter J. Meikle, Bronwyn A. Kingwell

Vol.102 Issue 6

健常男性被験者においてモキソニジンがアルドステロン/レニン比に及ぼす影響

Effect of Moxonidine on the Aldosterone/Renin Ratio in Healthy Male Volunteers

Ashraf H. Ahmed, Richard D. Gordon, Gregory Ward, Martin Wolley, Brett C. McWhinney, Jacobus P. Ungerer, Michael Stowasser

Vol.102 Issue 5

重症高トリグリセリド血症および膵炎を伴うアポリポ蛋白CII欠損症を惹起するAPOC2の新たなミスセンス変異が見出される

A Novel APOC2 Missense Mutation Causing Apolipoprotein C-II Deficiency with Severe Triglyceridemia and Pancreatitis

Masako Ueda, Richard L. Dunbar, Anna Wolska, Tracey U. Sikora, Maria del Rosario Escobar, Naomi Seliktar, Emil deGoma, Stephanie DerOhannessian, Linda Morrell, Adam D. McIntyre,   Frances Burke, Denis Sviridov, Marcelo Amar, Robert D. Shamburek, Lita Freeman, Robert A. Hegele, Alan T. Remaley, Daniel J. Rader

Vol.102 Issue 5

SGA性低身長児におけるACAN遺伝子変異および成長ホルモン治療に対する反応性

ACAN gene mutations in short children born SGA and response to Growth Hormone treatment

Manouk van der Steen, Rolph Pfundt, Stephan J.W.H. Maas, Willie M. Bakker-van Waarde, Roelof J. Odink, Anita C.S. Hokken-Koelega

Vol.102 Issue 5

膵・消化管神経内分泌腫瘍の追跡調査における機能的画像検査:臨床的有用性と適応

Functional Imaging in the Follow-up of Enteropancreatic Neuroendocrine Tumors: Clinical Usefulness and Indications.

Elettra Merola, Marianne E. Pavel, Francesco Panzuto, Gabriele Capurso, Noemi Cicchese, Anja Rinke, Thomas M. Gress, Elsa Iannicelli, Daniela Prosperi, Patrizia Pizzichini, Vikas Prasad, Patrizia Kump, Rainer Lipp, Stefano Partelli, Massimo Falconi, Bertram Wiedenmann, Gianfranco Delle Fave

Vol.102 Issue 5

1型糖尿病患者の十二指腸粘膜は炎症像および微生物叢において特徴的所見を示す

Duodenal mucosa of patients with type 1 diabetes shows distinctive inflammatory profile and microbiota

Silvia Pellegrini, Valeria Sordi, Andrea Mario Bolla, Diego Saita, Roberto Ferrarese, Filippo Canducci, Massimo Clementi, Francesca Invernizzi, Alberto Mariani, Riccardo Bonfanti, Graziano Barera, Pier Alberto Testoni, Claudio Doglioni, Emanuele Bosi, Lorenzo Piemonti

Vol.102 Issue 5

脂肪異栄養症患児におけるメトレレプチンの効果

Effects of Metreleptin in Pediatric Patients with Lipodystrophy

Rebecca J. Brown, Cristina Adelia Meehan, Elaine Cochran, Kristina I. Rother, David E. Kleiner, Mary Walter, Phillip Gorden

Vol.102 Issue 5

代謝健全性の決定因子としての心肺適応能および脂肪蓄積-2つの双生児対象コホート研究のプール解析

Cardiorespiratory fitness and adiposity as determinants of metabolic health - pooled analysis of two twin cohorts

Sakari Jukarainen, Rene Holst, Christine Dalgard, Paivi Piirila, Jesper Lundbom, Antti Hakkarainen, Nina Lundbom, Aila Rissanen, Jaakko Kaprio, Kirsten Ohm Kyvik, Thorkild I.A. Sorensen, Kirsi H. Pietilainen

Vol.102 Issue 5

父系遺伝するDLK1の欠失は家族性中枢性思春期早発症と関連する

Paternally Inherited DLK1 Deletion Associated with Familial Central Precocious Puberty

Andrew Dauber, Marina Cunha-Silva, Delanie B. Macedo, Vinicius N. Brito, Ana Paula Abreu, Stephanie A. Roberts, Luciana R. Montenegro, Melissa Andrew, Andrew Kirby, Matthew T. Weirauch, Guillaume Labilloy, Danielle S. Bessa, Rona S. Carroll, Dakota C. Jacobs, Patrick E. Chappell, Berenice B. Mendonca, David Haig, Ursula B. Kaiser, Ana Claudia Latronico

Vol.102 Issue 5

2型脱ヨード酵素のThr92Ala変異は酵素活性が低下しており甲状腺切除後の患者においては血清T3値の低下を惹起する

DIO2 Thr92Ala reduces deiodinase-2 activity and serum-T3 levels in thyroid-deficient patients

Maria Grazia Castagna, Monica Dentice, Silvia Cantara, Raffaele Ambrosio, Fabio Maino, Tommaso Porcelli, Carlotta Marzocchi, Corrado Garbi, Furio Pacini, Domenico Salvatore

Vol.102 Issue 5

長時間作用型CTP修飾ヒト型成長ホルモン(MOD-4023):成長ホルモン欠損症の小児を対象とした安全性・用量設定試験の結果

Long-Acting CTP-Modified hGH (MOD-4023): Results of a Safety and Dose-Finding Study in GHD Children

Nataliya Zelinska, Violeta Iotova, Julia Skorodok, Oleg Malievsky, Valentina Peterkova, Lubov Samsonova, Ron G. Rosenfeld, Zvi Zadik, Michal Jaron-Mendelson, Ronit Koren, Leanne Amitzi, Dmitri Raduk, Oren Hershkovitz, Gili Hart

Vol.102 Issue 5

子宮筋腫におけるプロテアーゼADAMTSによるバーシカンのタンパク質分解と、それが性ステロイド受容体の発現に与える影響

Versican Proteolysis by ADAMTS Proteases and its Influence on Sex Steroid Receptor Expression in Uterine Leiomyoma

Ndeye-Aicha Gueye, Timothy J. Mead, Christopher D. Koch, Charles V. Biscotti, Tommaso Falcone, Suneel S. Apte

Vol.102 Issue 5

動的リスク層別化の改善と、TERT変異を伴う分化型甲状腺癌の予後群

Refining dynamic risk stratification and prognostic groups for differentiated thyroid cancer with TERT mutations

Tae Hyuk Kim, Chang-Seok Ki, Hye Seung Kim, Kyunga Kim, Jun-Ho Choe, Jung-Han Kim, Jee Soo Kim, Young Lyun Oh, Soo Yeon Hahn, Jung Hee Shin, Hye Won Jang, Sun Wook Kim, Jae Hoon Chung